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OSTEOGENIC ACTIVITY OF THE FOURTEEN TYPES OF HUMAN BONE MORPHOGENETIC PROTEINS (BMPS)

Journal of Bone and Joint Surgery · 2003 · Vol. 85(8) · pp. 1544–1552

Hongwei Cheng✉(University of Chicago Medical Center)Wei Jiang(Baidu (China))Frank M. Phillips(Psyadon Pharmaceuticals (United States))Rex C. Haydon(Peng Huanwu Center for Fundamental Theory)Ying Peng(Michigan Department of Education)Lan Zhou(Hue University)Hue H. Luu(Miami Dermatology and Laser Institute)Naili An(Instituto Benjamin Constant)Benjamin N. Breyer(Universidad Panamericana)Pantila Vanichakarn(Szent János Kórház)J. Szatkowski(Universidad de Jaén)Jung Tak Park(Hejian People's Hospital)Tong‐Chuan He(University of Chicago)

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Abstract

A comprehensive analysis of the osteogenic activity of fourteen types of BMPs in osteoblastic progenitor cells was conducted. Our results suggest an osteogenic hierarchical model in which BMP-2, 6, and 9 may play an important role in inducing osteoblast differentiation of mesenchymal stem cells. In contrast, most BMPs are able to stimulate osteogenesis in mature osteoblasts.

Bone fractures and treatments Bone Tissue Engineering Materials TGF-β signaling in diseasesAlkaline phosphataseOsteocalcinBone morphogenetic proteinBone morphogenetic protein 2ChemistryMesenchymal stem cellProgenitor cellBone morphogenetic protein 7Cell biologyOsteoblast

MeSH terms

AdenoviridaeAlkaline PhosphataseAnimalsCell LineHumansMesodermOsteoblastsOsteocytesOsteogenesisOsteosarcomaStem CellsTumor Cells, CulturedBone DensityGene Transfer TechniquesBone Morphogenetic Proteins

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