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Sleep-promoting effects of endogenous pyrogen (interleukin-1)

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 1984 · Vol. 246(6) · pp. R994–R999

James M. Krueger✉(Institut Pasteur)James Walter(Institut Pasteur)C A Dinarello(Institut Pasteur)S. M. Wolff(Rosalind Franklin University of Medicine and Science)L Chedid(Rosalind Franklin University of Medicine and Science)

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Abstract

When infused into the lateral cerebral ventricles of rabbits, human endogenous pyrogen (EP) preparations induced dose-dependent increases in slow-wave sleep concomitant with increasing body temperature. Heating EP to 70 degrees C destroyed its sleep-promoting and pyrogenic activity. Anisomycin (an antipyretic) prevented EP from increasing body temperature without affecting its sleep-promoting activity. Intravenous injection of EP induced fever and transient increases in slow-wave sleep but failed to induce prolonged increases in slow-wave sleep. We conclude that the somnogenic activity of EP is not secondary to its pyrogenic activity.

Sleep and Wakefulness Research Neuroscience of respiration and sleep Neuroscience and Neuropharmacology ResearchEndogenySleep (system call)EndocrinologySlow-wave sleepThermoregulationInternal medicineSleep inductionChemistryMedicineAnisomycin