article Open AccessTop 1% cited
The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing
Clinical Cancer Research · 2015 · Vol. 22(1) · pp. 259–267
Teresa Helsten✉(Center for Personalized Cancer Treatment)Sheryl K. Elkin(Inotek Pharmaceuticals (United States))Elisa Arthur(Center for Personalized Cancer Treatment)Brett N. Tomson(Inotek Pharmaceuticals (United States))Jennifer Carter(Inotek Pharmaceuticals (United States))Razelle Kurzrock(Center for Personalized Cancer Treatment)
Abstract
FGFR aberrations are common in a wide variety of cancers, with the majority being gene amplifications or activating mutations. These data suggest that FGFR inhibition could be an important therapeutic option across multiple tumor types.
Fibroblast Growth Factor ResearchEpigenetics and DNA MethylationCancer, Hypoxia, and MetabolismFibroblast growth factor receptorCancer researchCancerMalignancyEndometrial cancerMedicineBiologyFibroblast growth factor receptor 1Breast cancerOncology
MeSH terms
FemaleGene AmplificationHumansMaleMutationNeoplasmsTranslocation, GeneticGenetic VariationReceptors, Fibroblast Growth FactorGene Expression ProfilingHigh-Throughput Nucleotide Sequencing
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References
An Integrative Genomic and Proteomic Analysis of PIK3CA, PTEN, and AKT Mutations in Breast Cancer
Cancer Research · 2008 · 1,033 citations
Frequent and Focal <i>FGFR1</i> Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer
Science Translational Medicine · 2010 · 821 citations
Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing
Nature Biotechnology · 2013 · 2,153 citations
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