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Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring

Journal of Nutrition · 2005 · Vol. 135(6) · pp. 1382–1386
Karen A. LillycropEmma PhillipsAlan A. JacksonMark A. HansonGraham C. Burdge
Birth, Development, and HealthEpigenetics and DNA MethylationGestational Diabetes Research and ManagementEpigeneticsBiologyDNA methylationOffspringMethylationGene expressionEndocrinologyInternal medicineGlucocorticoid receptorPeroxisome proliferator-activated receptor

MeSH terms

AnimalsAnimals, NewbornFemaleFolic AcidGene Expression RegulationLiverPregnancyPregnancy, AnimalPrenatal Exposure Delayed EffectsReceptors, GlucocorticoidRNA, MessengerRats, WistarDiet, Protein-RestrictedDNA MethylationAcyl-CoA Oxidase
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Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring · Scinovex