article Open AccessTop 1% cited
The PRECIS-2 tool: designing trials that are fit for purpose
BMJ · 2015 · Vol. 350(may08 1) · pp. h2147–h2147
Kirsty Loudon✉(University of Aberdeen)Shaun Treweek(University of Aberdeen)Frank Sullivan(North York General Hospital)Peter T. Donnan(University of Dundee)Kevin E. Thorpe(3M (United States))Merrick Zwarenstein(Western University)
Abstract
This paper presents PRECIS-2-a validated, improved version of the tool-together with guidance for how to use it PRECIS-2 has nine domains including three new ones (recruitment, setting, and organisation), each scored on a 5-point Likert continuum (from 1=very explanatory "ideal conditions" to 5=very pragmatic "usual care conditions") so that trialists, clinicians, and policymakers can more easily consider whether design decisions match their intended purpose on 2 August
Meta-analysis and systematic reviewsHealth Systems, Economic Evaluations, Quality of LifeDementia and Cognitive Impairment ResearchFlexibility (engineering)Computer scienceMatching (statistics)Domain (mathematical analysis)Outcome (game theory)Clinical trialMedical physicsManagement scienceSoftware engineeringMedicine
MeSH terms
Decision Support TechniquesHumansResearch DesignRandomized Controlled Trials as TopicPatient Selection
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References
Explanatory and Pragmatic Attitudes in Therapeutical Trials
Journal of Clinical Epidemiology · 2009 · 1,257 citations
A pragmatic–explanatory continuum indicator summary (PRECIS): a tool to help trial designers
Journal of Clinical Epidemiology · 2009 · 1,383 citations
Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
New England Journal of Medicine · 2000 · 12,769 citations
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