article Open AccessTop 10% cited
Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases.
Molecular Biology and Evolution · 1992 · Vol. 9(4) · pp. 678–87
Koichiro Tamura✉(Tokyo Metropolitan University)
Abstract
A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.
RNA and protein synthesis mechanismsGenomics and Phylogenetic StudiesMachine Learning in BioinformaticsTransversionBiologyTransition (genetics)Mitochondrial DNAGeneticsNucleotideDNAGC-contentContent (measure theory)Simple (philosophy)
MeSH terms
AnimalsBase CompositionComputer SimulationCytosineDNADNA, MitochondrialDrosophilaGenetic TechniquesGuanosineMathematicsModels, Genetic
Funding
- National Eye Institute
Citations
2,168
FWCI
3.73
field-weighted impact
References
12
Percentile
94%
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References
Estimation of evolutionary distance between nucleotide sequences.
Molecular Biology and Evolution · 1984 · 969 citations
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