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The claudin gene family: expression in normal and neoplastic tissues

BMC Cancer · 2006 · Vol. 6(1) · pp. 186–186

Kyle J. Hewitt✉(National Institute on Aging)Rachana Agarwal(National Institute on Aging)Patrice J. Morin(National Institute on Aging)

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Abstract

Our study confirms previously known CLDN gene expression patterns and identifies new ones, which may have applications in the detection, prognosis and therapy of several human cancers. In particular we identify several malignancies that express CLDN3 and CLDN4. These cancers may represent ideal candidates for a novel therapy being developed based on CPE, a toxin that specifically binds claudin-3 and claudin-4.

Barrier Structure and Function Studies Neurological Disease Mechanisms and Treatments Gut microbiota and healthClaudinCancerBiologyGeneCancer researchMedicineBioinformaticsGeneticsTight junction

MeSH terms

Amino Acid SequenceComputer SystemsMultigene FamilyHumansImage Processing, Computer-AssistedMembrane ProteinsMolecular Sequence DataNeoplasmsPhylogenyCluster AnalysisSequence Homology, Amino AcidReverse Transcriptase Polymerase Chain ReactionGene Expression ProfilingClaudin-1

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