articleTop 1% cited

U-50,488: a selective and structurally novel non-Mu (kappa) opioid agonist.

Journal of Pharmacology and Experimental Therapeutics · 1983 · Vol. 224(1) · pp. 7–12

Philip F. VonVoigtlander✉Robert A. LahtiJames H. Ludens

Inflammatory mediators and NSAID effects Receptor Mechanisms and Signaling Neuropeptides and Animal PhysiologyAgonist(+)-NaloxoneMorphineOpioidChemistryκ-opioid receptorPharmacologyAnalgesicDiprenorphineμ-opioid receptor

MeSH terms

Adrenal Cortex HormonesAnalgesics, OpioidAnimalsBrainDiureticsDrug ToleranceHumansMaleMotor ActivityNarcoticsPituitary-Adrenal SystemPyrrolidinesRats, Inbred StrainsReceptors, OpioidReceptors, Opioid, kappa

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815

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34.13

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Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

Proceedings of the National Academy of Sciences · 1988 · 4,701 citations

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