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Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.
Journal of Pharmacology and Experimental Therapeutics · 1994 · Vol. 270(1) · pp. 228–235
Martine Clozel✉(Roche (Switzerland))Volker BreuGillian A. GrayBarbara KalinaB M LöfflerKaspar F. BurriJean‐Marie CassalGeorges HirthMichael MüllerWerner Neidhart
Nitric Oxide and Endothelin EffectsBosentanAgonistEndothelin receptorReceptorChemistryAntagonistPharmacologyEndocrinologyInternal medicineMedicine
MeSH terms
BosentanAdministration, OralAmino Acid SequenceAnimalsBinding, CompetitiveCricetinaeHumansInsectaIodine RadioisotopesKineticsMaleMolecular Sequence DataRabbitsRats, Inbred WKYSensitivity and Specificity
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