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Psychological well‐being in patients on ‘adequate’ doses of <scp>l</scp>‐thyroxine: results of a large, controlled community‐based questionnaire study

Clinical Endocrinology · 2002 · Vol. 57(5) · pp. 577–585

Ponnusamy Saravanan(Bristol Royal Infirmary)W Chau(Bristol Royal Infirmary)Nehezi M. Roberts(Bristol Hospital)Kavita Vedhara(University of Bristol)Rosemary Greenwood(Bristol Royal Infirmary)Colin Dayan✉(Bristol Royal Infirmary)

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Abstract

This community-based study is the first evidence to indicate that patients on thyroxine replacement even with a normal TSH display significant impairment in psychological well-being compared to controls of similar age and sex. In view of the large numbers of people on thyroxine replacement, we believe that these differences, although not large, could contribute to significant psychological morbidity in a substantial number of individuals.

Thyroid Disorders and Treatments Thyroid Cancer Diagnosis and Treatment Pituitary Gland Disorders and TreatmentsGeneral Health QuestionnaireMedicineLethargyPopulationHormone replacementInternal medicineHormonePsychiatryMental health

MeSH terms

AdolescentAdultAgedDrug Administration ScheduleFemaleHumansHypothyroidismMaleMiddle AgedPsychiatric Status Rating ScalesSurveys and QuestionnairesRegression AnalysisThyrotropinThyroxineChi-Square Distribution

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506

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98%

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References

The validity of two versions of the GHQ in the WHO study of mental illness in general health care