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Acute Exacerbations of Chronic Obstructive Pulmonary Disease Are Accompanied by Elevations of Plasma Fibrinogen and Serum IL-6 Levels

Thrombosis and Haemostasis · 2000 · Vol. 84(08) · pp. 210–215

Terence Seemungal✉Peter MacCallumElizabeth PaulGavin C. DonaldsonAngshu BhowmikDonald J. JeffriesT W MeadeJadwiga A. Wedzicha(Queen Mary University of London)

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Abstract

Plasma fibrinogen levels were elevated in stable patients with COPD and may contribute to the increased cardiovascular morbidity and mortality in these patients. COPD exacerbations increased serum IL-6 levels, leading to a rise in plasma fibrinogen. Thus acute rather than chronic infection may have a role in predisposing to coronary heart disease or stroke.

Chronic Obstructive Pulmonary Disease (COPD) Research Respiratory Support and Mechanisms Asthma and respiratory diseasesMedicineExacerbationFibrinogenInternal medicineCOPDSpirometryGastroenterologyCardiologyRisk factorRespiratory system

MeSH terms

AgedBlood Gas AnalysisFemaleFibrinogenForced Expiratory VolumeHumansLung Diseases, ObstructiveMaleMiddle AgedPeak Expiratory Flow RateProspective StudiesRespiratory Tract InfectionsRisk FactorsVital CapacityCohort Studies