Phytochemical analysis and in-vitro antibacterial activity of aqueous methanolic extract of Strychnos nux vomica leaves

Abstract

Strychnos nux vomica is a non edible tree with a strong content of two poisonous alkaloids, strychnine and brucine. Qualitative phytochemical analysis and antimicrobial activity of the aqueous methanolic extract of its leaves were studied. Alkaloids, triterpenes, oils & fats, phenol, tannins and flavonoids were present. Escherichia coli Enterobacter, Staphylococcus aureus, and Pseudomonas showed susceptibility but Salmonella typhimurium survived the inhibition. Minimal inhibitory concentration of the extract for E. coliafter an overnight incubation was found to be 0.25 mg. In the present study the antibacterial activity of Strychnos nux vomica leaves showed inhibitory effects on selective bacteria which could be used to control these microbes.