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Effect of food on the relative bioavailability of two oral formulations of posaconazole in healthy adults
British Journal of Clinical Pharmacology · 2003 · Vol. 57(2) · pp. 218–222
Rachel Courtney✉(AIL Research (United States))David WexlerElaine RadwanskiJosephine LimMark Laughlin
Abstract
The suspension formulation of posaconazole was associated with enhanced systemic exposure and increased relative bioavailability compared with the tablet. Food substantially enhanced the rate and extent of posaconazole absorption in healthy subjects.
Pharmaceutical studies and practicesMedication Adherence and ComplianceAntifungal resistance and susceptibilityPosaconazoleBioavailabilityCmaxCrossover studyPharmacokineticsMealMedicinePharmacologyOral administrationChemistry
MeSH terms
Administration, OralAdolescentAdultAntifungal AgentsBiological AvailabilityFoodHumansMaleMiddle AgedTabletsTriazolesFood-Drug InteractionsCross-Over Studies
Citations
324
FWCI
9.74
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14
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98%
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