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The MEME Suite

Nucleic Acids Research · 2015 · Vol. 43(W1) · pp. W39–W49

Timothy L. Bailey✉James Johnson(University of Queensland)Charles E. Grant(University of Washington)William Stafford Noble(University of Washington)

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Abstract

The MEME Suite is a powerful, integrated set of web-based tools for studying sequence motifs in proteins, DNA and RNA. Such motifs encode many biological functions, and their detection and characterization is important in the study of molecular interactions in the cell, including the regulation of gene expression. Since the previous description of the MEME Suite in the 2009 Nucleic Acids Research Web Server Issue, we have added six new tools. Here we describe the capabilities of all the tools within the suite, give advice on their best use and provide several case studies to illustrate how to combine the results of various MEME Suite tools for successful motif-based analyses. The MEME Suite is freely available for academic use at http://meme-suite.org, and source code is also available for download and local installation.

RNA and protein synthesis mechanisms Genomics and Chromatin Dynamics Gene expression and cancer classificationSuiteBiologyComputational biologyENCODEWeb serverSource codeRanComputer scienceWorld Wide WebThe Internet

MeSH terms

Amino Acid MotifsProtein Sorting SignalsDNAPlasmodium falciparumSoftwareProtozoan ProteinsSequence Analysis, DNASequence Analysis, RNAReceptors, CalcitriolInternetSequence Analysis, ProteinProtein Interaction Domains and MotifsNucleotide Motifs

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