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Independent association of extent of resection with survival in patients with malignant brain astrocytoma

Journal of neurosurgery · 2008 · Vol. 110(1) · pp. 156–162

Matthew J. McGirt✉(Johns Hopkins Medicine)Kaisorn L. Chaichana(Johns Hopkins University)Muraya Gathinji(Johns Hopkins University)Frank J. Attenello(Johns Hopkins University)Khoi D. Than(Johns Hopkins University)Alessandro Olivi(Johns Hopkins University)Jon Weingart(Johns Hopkins University)Henry Brem(Johns Hopkins University)Alf redo Quiñones-Hinojosa(Johns Hopkins University)

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Abstract

In the authors' experience with both primary and secondary resection of malignant brain astrocytomas, increasing extent of resection was associated with improved survival independent of age, degree of disability, WHO grade, or subsequent treatment modalities used. The maximum extent of resection should be safely attempted while minimizing the risk of surgically induced neurological injury.

Glioma Diagnosis and Treatment Meningioma and schwannoma management Brain Metastases and TreatmentMedicineAstrocytomaMagnetic resonance imagingSurgeryResectionTemozolomideRadiologyGliomaRadiation therapy

MeSH terms

TemozolomideAgedAnalysis of VarianceAstrocytomaBrain NeoplasmsCarmustineCombined Modality TherapyDacarbazineDecanoic AcidsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPolyesters

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Clinical practice guidelines for the management of adult diffuse gliomas