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A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck
BMC Cancer · 2006 · Vol. 6(1) · pp. 28–28
Wilfried Budach✉(Düsseldorf University Hospital)Thomas Hehr(University Children's Hospital Tübingen)Volker Budach(Charité - Universitätsmedizin Berlin)Claus Belka(University Children's Hospital Tübingen)Klaus Dietz(University of Tübingen)
Abstract
RT combined with simultaneous 5-FU, cisplatin, carboplatin, and mitomycin C as single drug or combinations of 5-FU with one of the other drugs results in a large survival advantage irrespective the employed radiation schedule. If radiation therapy is used as single modality, hyperfractionation leads to a significant improvement of overall survival. Accelerated radiation therapy alone, especially when given as split course radiation schedule or extremely accelerated treatments with decreased total dose, does not increase overall survival.
Head and Neck Cancer StudiesHead and Neck Surgical OncologySalivary Gland Tumors Diagnosis and TreatmentMedicineSurgical oncologyRadiation therapyHead and neck squamous-cell carcinomaHead and neckOncologyBasal cellChemotherapyInternal medicineHead and neck cancer
MeSH terms
Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, Squamous CellCisplatinCombined Modality TherapyFluorouracilHead and Neck NeoplasmsHumansSurvival AnalysisRandomized Controlled Trials as TopicCarboplatinMitomycinTreatment OutcomeDose Fractionation, Radiation
Citations
296
FWCI
20.87
field-weighted impact
References
50
Percentile
100%
vs. same field & year
Citations per year
References
A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer
Radiotherapy and Oncology · 1997 · 472 citations
Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: results of the EORTC 22851 randomized trial
Radiotherapy and Oncology · 1997 · 505 citations
Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: final analysis of a randomized trial of the EORTC cooperative group of radiotherapy
Radiotherapy and Oncology · 1992 · 682 citations
Randomized Trial of Radiation Therapy Versus Concomitant Chemotherapy and Radiation Therapy for Advanced-Stage Oropharynx Carcinoma
JNCI Journal of the National Cancer Institute · 1999 · 1,064 citations
A radiation therapy oncology group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003
International Journal of Radiation Oncology*Biology*Physics · 2000 · 1,357 citations
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