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The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

Nature Medicine · 2001 · Vol. 7(8) · pp. 941–946

Toshimasa Yamauchi✉(The University of Tokyo)Junji Kamon(The University of Tokyo)Hironori Waki(The University of Tokyo)Yasuo Terauchi(The University of Tokyo)Naoto Kubota(The University of Tokyo)Kazuo Hara(The University of Tokyo)Yasukiyo Mori(Centre National de la Recherche Scientifique)Tatsuro Ide(Kyorin University)Koji Murakami(Kyorin University)Nobuyo Tsuboyama-Kasaoka(National Institute of Infectious Diseases)Osamu Ezaki(National Institute of Infectious Diseases)Y Akanuma(Institute for Adult Diseases Asahi Life Foundation)Oksana Gavrilova(National Institute of Diabetes and Digestive and Kidney Diseases)Charles Vinson(National Cancer Institute)Marc L. Reitman(National Institute of Diabetes and Digestive and Kidney Diseases)Hiroyuki Kagechika(The University of Tokyo)Koichi Shudo(The University of Tokyo)Madoka Yoda(Showa University)Yasuko Nakano(Showa Pharmaceutical University)Kazuyuki Tobe(The University of Tokyo)R Nagai(The University of Tokyo)Satoshi Kimura(The University of Tokyo)Motowo Tomita(Showa University)Philippe Froguel(Centre National de la Recherche Scientifique)Takashi Kadowaki(The University of Tokyo)

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Adipokines, Inflammation, and Metabolic Diseases Adipose Tissue and Metabolism Regulation of Appetite and ObesityAdiponectinInsulin resistanceInternal medicineEndocrinologyType 2 diabetesLeptinAdipocyteInsulinMetabolic syndromeBiology

MeSH terms

Adipose TissueAmino Acid SequenceAnimalsInsulin ResistanceMolecular Sequence DataObesityOxidation-ReductionProteinsTranscription FactorsTriglyceridesSignal TransductionReceptors, Cytoplasmic and NuclearLeptinIntercellular Signaling Peptides and ProteinsMice

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