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Effects of Blood Pressure Lowering With Perindopril and Indapamide Therapy on Dementia and Cognitive Decline in Patients With Cerebrovascular Disease

Archives of Internal Medicine · 2003 · Vol. 163(9) · pp. 1069–1069
Christophe Tzourio

Abstract

Active treatment was associated with reduced risks of dementia and cognitive decline associated with recurrent stroke. These findings further support the recommendation that blood pressure lowering with perindopril and indapamide therapy be considered for all patients with cerebrovascular disease.

Cerebrovascular and Carotid Artery DiseasesDementia and Cognitive Impairment ResearchBlood Pressure and Hypertension StudiesIndapamideDementiaMedicineCognitive declineStroke (engine)Confidence intervalPerindoprilPlaceboInternal medicineBlood pressure

MeSH terms

AgedAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsBlood PressureCerebrovascular DisordersCognitionCognition DisordersDementiaDiureticsDouble-Blind MethodFemaleHumansHypertensionIndapamideMale

Funding

  • University of Sydney
  • Servier
  • Medical Research Council
  • National Health and Medical Research Council
  • Health Research Council of New Zealand
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