article Open AccessTop 1% cited

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

Nature Cell Biology · 2000 · Vol. 2(10) · pp. 737–744

Gabriele Bergers✉(University of California, San Francisco)Rolf A. Brekken(Hope Heart Institute)Gerald McMahonThiennu H. Vu(University of California, San Francisco)Takeshi Itoh(Kyoto University)Kazuhiko Tamaki(Daiichi-Sankyo (Japan))Kazuhiko Tanzawa(Daiichi-Sankyo (Japan))Philip E. Thorpe(The University of Texas Southwestern Medical Center)Shigeyoshi Itohara(RIKEN Center for Brain Science)Zena Werb(UCSF Helen Diller Family Comprehensive Cancer Center)Douglas Hanahan(UCSF Helen Diller Family Comprehensive Cancer Center)

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Protease and Inhibitor Mechanisms Proteoglycans and glycosaminoglycans research Angiogenesis and VEGF in CancerAngiogenesisMatrix metalloproteinaseGelatinase ACell biologyCancer researchDownregulation and upregulationNeovascularizationGelatinaseVascular endothelial growth factorBiology

MeSH terms

AcetamidesAnimalsCell Transformation, NeoplasticGenes, SwitchIslets of LangerhansLymphokinesMice, TransgenicNeovascularization, PathologicPancreatic NeoplasmsTissue DistributionSignal TransductionEndothelial Growth FactorsReceptors, Growth FactorMatrix Metalloproteinase 9Receptor Protein-Tyrosine Kinases

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Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis