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Studies on the Drugs for Peptic Ulcer. A Reliable Method for Producing Stress Ulcer in Rats.
Chemical and Pharmaceutical Bulletin · 1964 · Vol. 12(4) · pp. 465–472
Keijiro Takagi✉(The University of Tokyo)Yutaka Kasuya(The University of Tokyo)Kazuo Watanabe(The University of Tokyo)
Abstract
A simple and reliable method for production of gastric ulcer on rats by stress was described. Rats fixed on boards were immersed in water of 25°to the depth of xiphoide. After 20 hours, marked gastric erosions were found in the glandular portion of the stomach. This stress is more favourable than other stresses as cold, restraint, or emotional stress by stress box in view of incidence and mortality. Anticholinergics or central depressants effectively inhibited the ulceration and combination of both drugs suppressed it more effectively than single administration of each drug.
Pharmacological Effects of Natural CompoundsHelicobacter pylori-related gastroenterology studiesGastrointestinal motility and disordersStress ulcerPeptic ulcerStomachUlcer indexChemistryDrugGastroenterologyPharmacologyIncidence (geometry)Internal medicine
MeSH terms
AtropineHypnotics and SedativesParasympatholyticsPeptic UlcerPharmacologyResearchStomach UlcerStress, PhysiologicalTranquilizing AgentsUlcerRats
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