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The Structural Biology of Expression and Function of Tissue Factor

Thrombosis and Haemostasis · 1991 · Vol. 66(01) · pp. 067–079

Thomas S. Edgington✉(Scripps Research Institute)Nigel Mackman(Scripps Research Institute)Korbinian Brand(Scripps Research Institute)Wolfram Ruf(Scripps Research Institute)

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Abstract

Analysis of the structural biology of TF provides insights into the both the expression of the gene and the function of this cell surface receptor in the initiation of the coagulation protease cascades. The advance of information may permit inferential hypotheses for the structural biology of other cofactor regulated catalytic steps in blood coagulation.

Blood Coagulation and Thrombosis Mechanisms Protease and Inhibitor Mechanisms Cell Adhesion Molecules ResearchTissue factorCoagulationFunction (biology)BiologyGene expressionComputational biologyCell biologyExpression (computer science)Structural biologyRegulation of gene expression

MeSH terms

Amino Acid SequenceAnimalsBiological EvolutionGene Expression RegulationHumansMolecular Sequence DataReceptors, ImmunologicRNA, MessengerSequence Homology, Nucleic AcidThromboplastinReceptors, Interferon

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