articleTop 1% cited

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

Nature Medicine · 2000 · Vol. 6(11) · pp. 1229–1234

Eric Lagasse✉(Applied StemCell (United States))Heather Connors(Applied StemCell (United States))Muhsen Al-Dhalimy(Oregon Health & Science University)Michael J. Reitsma(StemCells (United States))Monika Dohse(Applied StemCell (United States))Linda J. Osborne(Applied StemCell (United States))Xin Wang(Oregon Health & Science University)Milton J. Finegold(Texas Children's Hospital)Irving L. Weissman(Stanford University)Markus Grompe(Oregon Health & Science University)

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Liver physiology and pathology Pancreatic function and diabetes Pluripotent Stem Cells ResearchHaematopoiesisStem cellBiologyProgenitor cellBone marrowInduced pluripotent stem cellCell biologyAdult stem cellClinical uses of mesenchymal stem cellsHematopoietic stem cell

MeSH terms

AnimalsBone Marrow CellsCell DifferentiationCell SeparationHematopoietic Stem CellsHydrolasesLiverLiver RegenerationMice, Inbred C57BLMice, Inbred StrainsWhole-Body IrradiationCell TransplantationMice, KnockoutTyrosinemiasHepatocytes

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Bone Marrow Stromal Stem Cells: Nature, Biology, and Potential Applications