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Induction of hepatitis A virus-neutralizing antibody by a virus-specific synthetic peptide
Journal of Virology · 1985 · Vol. 55(3) · pp. 836–839
Abstract
Comparative surface feature analyses of the VP1 sequences of hepatitis A virus (HAV) and poliovirus type 1 allowed an alignment of the two sequences and an identification of probable HAV neutralization antigenic sites. A synthetic peptide containing the HAV-specific amino acid sequence of one of these sites induced anti-HAV-neutralizing antibodies. It is concluded that a structural homology exists between the two viruses, despite minimal primary sequence conservation.
Viral gastroenteritis research and epidemiologyViral Infections and Immunology ResearchAnimal Virus Infections StudiesBiologyVirologyNeutralizationPeptide sequenceHepatitis a virusPoliovirusVirusAntibodyNeutralizing antibodyPeptide
MeSH terms
Amino Acid SequenceHepatovirusHepatitis AntibodiesNeutralization TestsViral ProteinsViral Structural ProteinsPoliovirus
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References
Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins
Journal of Molecular Biology · 1978 · 4,560 citations
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