articleTop 1% cited
Combined analysis of risk factors for SUDEP
Epilepsia · 2011 · Vol. 52(6) · pp. 1150–1159
Dale C. Hesdorffer✉(Columbia University)Torbjörn Tomson(Karolinska Institutet)Emma K. T. Benn(Columbia University)Josemir W. Sander(University College London)Lena Nilsson(Marie Cederschiöld University)Yvonne Langan(University College London)Thaddeus S. Walczak(University of Minnesota)Ettore Beghi(Mario Negri Institute for Pharmacological Research)Martin J. Brodie(University of Glasgow)Allen Hauser(Columbia University)for the ILAE Commission on Epidemiology; Subcommission on Mortality
Abstract
This analysis refines the identification of people with epilepsy that are at particular risk of SUDEP. The emerging profile indicates that people with early onset refractory symptomatic epilepsy with frequent GTCS and antiepileptic drug (AED) polytherapy are at higher risk. The results suggest that reduction of the number of GTCS is a priority, of more importance than reducing the number of AEDs. The role of AEDs and other treatment should be analyzed further in future studies.
Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesNeuroscience and Neuropharmacology ResearchLamotrigineEpilepsyMedicinePediatricsEtiologyUnivariate analysisRisk factorLogistic regressionPsychiatryInternal medicine
MeSH terms
AdolescentAdultAgedAnticonvulsantsDeath, SuddenEnglandEpilepsyFemaleHumansMaleMiddle AgedRisk FactorsScotlandSwedenUnited States
Citations
489
FWCI
18.36
field-weighted impact
References
17
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100%
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Citations per year
References
Sudden Unexpected Death in Epilepsy: Terminology and Definitions
Epilepsia · 1997 · 480 citations
Guidelines for epidemiologic studies on epilepsy
Epilepsia · 1993 · 1,183 citations
Guidelines for Epidemiologic Studies on Epilepsy
Epilepsia · 1993 · 1,349 citations
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