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CYP3A4 drug interactions: correlation of 10 <i>in vitro</i> probe substrates
British Journal of Clinical Pharmacology · 1999 · Vol. 48(5) · pp. 716–727
Abstract
It is recommended that multiple CYP3A4 probes, representing each substrate group, are used for the in vitro assessment of CYP3A4-mediated drug interactions.
Pharmacogenetics and Drug MetabolismPharmacological Effects and Toxicity StudiesDrug Transport and Resistance MechanismsCYP3A4DextromethorphanPharmacologyChemistryTriazolamHydroxylationCytochrome P450Drug metabolismStereochemistryBiochemistry
MeSH terms
Cytochrome P-450 Enzyme SystemPharmaceutical PreparationsEnzyme InhibitorsHumansMixed Function OxygenasesKineticsRecombinant ProteinsCytochrome P-450 CYP1A1Cytochrome P-450 CYP3ACytochrome P-450 Enzyme Inhibitors
Citations
335
FWCI
15.21
field-weighted impact
References
36
Percentile
99%
vs. same field & year
Citations per year
References
Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.
Molecular Pharmacology · 1989 · 535 citations
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